MO re Connections:
Business & Innovation Ecosystem

Where Big Ideas Belong
— and Businesses Grow

Columbia’s economy has always been rooted in education, healthcare, and service — but today, it’s also driven by innovation, entrepreneurship, and a thriving community of people building what’s next. Whether you’re launching a company, joining a high-growth team, or looking to invest in a place with momentum, Columbia offers more support, more talent, and more room to grow.

Columbia’s Economic Landscape At-A-Glance

Top Employers:

University of Missouri, MU Health Care, Veterans United Home Loans, EquipmentShare, and Boone Health

Startups & Growth Companies:

Dozens of high-growth startups in logistics tech, agtech, health innovation, and software

Innovation & R&D:

Anchored by a Tier 1 research university (Mizzou), multiple medical research centers, and tech incubators

Major Industries:

  • Healthcare & Life Sciences
  • Education & Research
  • Technology & Software
  • Advanced Manufacturing
  • Finance & Real Estate
  • Construction Tech & Logistics

Columbia’s unemployment rate remains below the national average , and the region’s job market is projected to grow by over 30% in the next decade.

— U.S. Bureau of Labor Statistics, Missouri Economic Research & Information Center

Start Something Big — or Join What’s Growing​

Columbia is an ideal launchpad for entrepreneurs, creators, and innovators. Here’s why:

  • REDI
    (Regional Economic Development Inc.) – Business attraction, expansion, and funding support
  • Innovation Hub @ MU
    Startup resources, coworking, and mentorship
  • The Missouri Innovation Center
    Incubator for biotech and scalable tech startups
  • Columbia Startup Weekend, 1 Million Cups, and CoMo Cooks
    Active community-driven events and programs

Startup Success Stories

Veterans United Home Loans

The nation’s largest VA lender with a strong tech culture

EquipmentShare

Building the future of construction and founded in Columbia

Paytient

Helping people across the country make better healthcare decisions by improving their ability to pay for care

Veterans United Home Loans

The nation’s largest VA lender with a strong tech culture

EquipmentShare

Building the future of construction and founded in Columbia

Paytient

Helping people across the country make better healthcare decisions by improving their ability to pay for care

A Collaborative Business Culture

Columbia’s size makes it easier to connect — with local leaders, partners, talent, and capital. You won’t get lost in the crowd here.

Events that bring entrepreneurs, professionals, and civic leaders together regularly

Local chambers and accelerators focused on inclusion and innovation
Access to regional funding sources and angel investor networks
Strong connections between the university and private sector

Great Support Team

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Joseph L.Mabie
Influencer

Columbia — By the Numbers

$325000

Median Home Price, (2025 YTD, CBOR)

0%

Cost of Living - below national avg (C2ER)

0%

unemployment rate (2025) – consistently below the national average

50%

Labor Force Participation

30%

% of Population with Bachelor’s Degree or Higher

1000+

Business Licenses Issued (2024)

0+

minutes average commute time (vs. ~27 minutes nationally)

Ready to Grow in Columbia?

Whether you’re an entrepreneur, executive, or someone looking to return and contribute, Columbia is more connected, more dynamic, and more ready for you than ever before.

Let us help you plug into the people, places, and programs shaping the next chapter of Columbia’s economy.